About Microdosing Psilocybin

MICRODOSING PSILOCYBIN

Microdosing Psilocybin has been used to aid in fighting depression and anxiety, while also increasing emotional empathy. It does this by mimicking serotonin by stimulating the “5-HT2A” serotonin receptor. Doing so increases BDNF (Brain Derived Neurotrophic Factor), which plays a significant role in Neurogenesis.

Neurogenesis is the process by which new neurons are formed in the brain to make new connections and networks. Professionals used to believe that neurogenesis stopped occurring at the age of 25 and that the brains neuron’s actually decreased with age. This thought process has been tested by microdosing mushrooms, and many believe that we may have been wrong to believe neurogenesis can not occur later in life.

Psilocybin is one of few compounds known to cause neurogenesis by acting on the hippocampus, a complex brain structure that has a major role in learning and memory. The increased stimulation in “5-HT2A” also increases glutamate which is responsible for memory, general cognition, and learning. Microdosing psilocybin causes parts of the brain which would normally not communicate together, to communicate with one another. These brain connections are made by decreasing the activity in our Default Mode Network (DMN), which is often a very over-used part of our brain.
The DMN in our brains is responsible for numerous mental activities such as thinking about the past/future and self-reflection. With an over-stimulated DMN, our mental thoughts may often lead to those of a depressed or anxious state. Since microdosing has been proven to slow down the activity of our DMN, it causes humans to naturally think in new ways which would otherwise be inaccessible to us. These new thought patterns help remove and forget about depressive thoughts altogether and allow people to be present in the current moment. This can also help people that suffer with PTSD, as they often are stuck in repetitive thought patterns.